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ADMET and Pharmacokinetic Studies:
Hits from screening campaigns will be confirmed through sensitive biological assays to determine whether the compound is effective in inhibiting or activating the molecular target under study. We also provide pharmacokinetic data, including metabolic and chemical stability, membrane permeability, solubility, inhibition of major metabolic enzymes and mutagenicity.

Natural product Scaffolds:
Synthesis of natural product scaffolds and small set of (20-40) optimized libraries containing natural product scaffolds.

Building Block Synthesis:
Design and synthesis of building blocks/scaffolds with multiple reactive sites from milligram to multi grams

Lead Design:
Design and synthesis of optimized small targeted libraries for lead generation. Active Pharmaceutical Intermediates: Design and synthesize optimized small molecule libraries around API’s.

File enrichment libraries:
Generation of libraries of compounds according to customers file enrichment needs.

Solid phase synthesis:
Screening library synthesis on solid support.

Process optimization:
Expedite the transfer of process from bench top to poilet plants using combinatorial technology.
 
News
  Industrial post-doctoral and research scientist Positions in Drug Discovery

Industrial postdoctoral and researcher scientist positions are available in our medicinal chemistry division.

The project will involve design and optimization of flexible synthetic strategies for preparation of small molecules for oncology research.

The applicants must have:

  • PhD in Organic/medicinal chemistry
  • 1-2 year's prior postdoctoral experience
  • a competitive publication record
  • strong knowledge in modern synthetic organic/medicinal chemistry and analytical chemistry.

Previous experience working with parallel library synthesis, DNA encoded libraries and antibody-drug-conjugate (ADC) is desirable.

Entry level postdoctoral researchers will be considered and those with advanced postdoctoral training could be eligible for a Research scientist position.

Send resume and contact information with references to: anny@creagenbio.com.

Also visit: http://www.creagenbio.com

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